HLA‐B*35–Restricted CD8 T Cell Epitopes in the Antigen 85 Complex ofMycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
The Immunodominant T-Cell Epitopes of the Mycolyl-Transferases of the Antigen 85 Complex of M. tuberculosis
The Ag85 complex is a 30-32 kDa family of three proteins (Ag85A, Ag85B, and Ag85C), which all three possess enzymatic mycolyl-transferase activity involved in the coupling of mycolic acids to the arabinogalactan of the cell wall and in the biogenesis of cord factor. By virtue of their strong potential to induce Th1-type immune responses, important for the control of intracellular infections, me...
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Although the effective immune response against Mycobacterium tuberculosis (M. tuberculosis, Mtb) is primarily due to cell-mediated immunity, the mechanisms by which T cells participate in the control of infection are still not completely understood. The importance of CD8+ T cells in the immune response to tuberculosis has been recognized by many researchers [1]. Experimental evidence from the m...
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The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrat...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2001
ISSN: 0022-1899,1537-6613
DOI: 10.1086/319267